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C3’s Blog

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Industry Publications

Waniger, S.; Wozniak E.; Biesecker K. Difficult-to-Express Proteins: Resolving Bioprocessing Challenges with a Scalable Perfusion Bioreactor. BioProcess International. 2017, 15(5)i:14-19.

Wozniak, E. and Biesecker, K. Perfusion Solutions for Therapeutic Development: Fail Fast, Fail Cheap. GEN Bioprocessing. 2017, 20-21.

Gramer, M. J.; Hirschel, M. D.; Sly, J. From Discovery to Clinic: A Robust Strategy for Rapid Development of Clinical Manufacturing Processes. Bioprocess Int. 2003, 1, 2–7.

Peer reviewed publications

Gramer M and Britton T. Antibody Production by a Hybridoma Cell Line at High Cell Density is Limited by Two Independent Mechanisms. Biotechnology and Bioengineering. 2002, 79(3); 277-283.

Gramer M, Maas J, Lieberman M. Use of hollow fiber systems for rapid and direct scale up of antibody production from hybridoma cell lines cultured in CL-1000 flasks using BD Cell MAb medium. Cytotechnology Short Communication. 2003, 42:155-162.

Gramer M and Poeschl D. Comparison of cell growth in T-flasks, in micro hollow fiber bioreactors, and in an industrial scale hollow fiber bioreactor system. Cytotechnology. 2000, 34:111-119.

Gramer M and Maas J. Optimal NS0 Cell Growth in a Hollow Fiber Bioreactor Requires Increased Serum Concentration or a Cholesterol Supplement on the Cell Side of the Fiber. Biotechnol. Prog. 2003, 19(6): 1762-1766.

Gramer, M. J.; Poeschl, D. M.; Conroy, M. J.; Hammer, B.E. Effect of Harvesting Protocol on Performance of a Hollow Fiber Bioreactor. Biotechnol. Bioeng. 1999, 65, 334–340.

Hirschel, M. D.; Gruenberg, M. L. An Automated Hollow Fiber System for the Large Scale Manufacture of Mammalian Cell Secreted Product. In Large Scale Cell Culture Technology; Lydersen, B. K., Ed.; Macmillan: New York, 1988; pp 113–144.

Gramer, M. J.; Poeschl, D. M. Screening Tool for Hollow Fiber Bioreactor Process Development. Biotechnol. Prog.1998, 14, 203–209.

Gramer, M. J.; Britton, T. L. Selection and Isolation of Cells for Optimal Growth in Hollow Fiber Bioreactors. Hybridoma 2000, 19, 407–412.